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Research


      My research focuses on applied mathematics, mathematical life sciences, and stochastic processes. I am using modern mathematical theory (probability theory, stochastic processes, differential equations, dynamical systems, spectral theory, graph theory, and statistics) to develop novel analytical theory and efficient computational methods of stochastic gene regulation networks and biochemical reaction networks, with the aim of understanding the stochastic dynamics and thermodynamics of complex cellular and subcellular processes far from equilibrium and with multiple time scales. This is a hotspot research field with highly interdisciplinary features.

      I am not only carrying out interdisciplinary research, but also actively engaged in high-level mathematical research with the aim of developing new mathematical theories related to natural sciences with full rigor and a high degree of abstraction. Some of the mathematical topics include Markov and semi-Markov processes, large deviation theory, stochastic analysis, and queuing theory.

      Stochastic dynamics of complex gene regulatory networks


    1. Accurate and efficient computations of stochastic gene networks
    2. Emergent properties of stochastic gene networks
    3. Poisson representation of gene networks
    4. Parameter inference and model selection based on single-cell data

      Mathematical theory of single-cell stochastic gene expression


    5. Discrete, continuous, and hybrid modeling of stochastic gene expression

    6. Analytical distributions of mRNA and protein numbers

    7. Analytical distributions of first passage times

    8. Steady-state and dynamical phase diagrams

    9. Coupled stochastic dynamics of gene expression, cell size, and cell cycle


    10. Frequency domain analysis of mRNA and protein fluctuations for lineage measurements

    11. Analytical distributions of mRNA and protein numbers/concentrations

    12. Analytical distributions of cell size

    13. Emergent concentration homeostasis

    14. Emergent cell-size homeostasis

    15. Theory of stochastic processes


    16. Multiscale model reduction

    17. Loop-erased circulation theory for Markov processes

    18. Limit theorems of stochastic chemical reaction networks

    19. Freidlin-Wentzell-type large deviations

    20. Donsker-Varadhan-type large deviations

    21. Maximal inequalities for Markov processes

    22. Nonequilibrium stochastic thermodynamics of molecular systems


    23. Cycle currents of molecular systems

    24. Entropy production of molecular systems

    25. Fluctuation relations

    26. Fluctuation-dissipation relations