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Research
My research focuses on applied mathematics, mathematical life sciences, and stochastic processes. I am using modern mathematical theory (probability theory, stochastic processes, differential equations, dynamical systems, spectral theory, graph theory, and statistics) to develop novel analytical theory and efficient computational methods of stochastic gene regulation networks and biochemical reaction networks, with the aim of understanding the stochastic dynamics and thermodynamics of complex cellular and subcellular processes far from equilibrium and with multiple time scales. This is a hotspot research field with highly interdisciplinary features.
I am not only carrying out interdisciplinary research, but also actively engaged in high-level mathematical research with the aim of developing new mathematical theories related to natural sciences with full rigor and a high degree of abstraction. Some of the mathematical topics include Markov and semi-Markov processes, large deviation theory, stochastic analysis, and queuing theory.
Stochastic dynamics of complex gene regulatory networks
Accurate and efficient computations of stochastic gene networks
Emergent properties of stochastic gene networks
Poisson representation of gene networks
Parameter inference and model selection based on single-cell data
Mathematical theory of single-cell stochastic gene expression
Discrete, continuous, and hybrid modeling of stochastic gene expression
Analytical distributions of mRNA and protein numbers
Analytical distributions of first passage times
Steady-state and dynamical phase diagrams
Coupled stochastic dynamics of gene expression, cell size, and cell cycle
Frequency domain analysis of mRNA and protein fluctuations for lineage measurements
Analytical distributions of mRNA and protein numbers/concentrations
Analytical distributions of cell size
Emergent concentration homeostasis
Emergent cell-size homeostasis
Theory of stochastic processes
Multiscale model reduction
Loop-erased circulation theory for Markov processes
Limit theorems of stochastic chemical reaction networks
Freidlin-Wentzell-type large deviations
Donsker-Varadhan-type large deviations
Maximal inequalities for Markov processes
Nonequilibrium stochastic thermodynamics of molecular systems
Cycle currents of molecular systems
Entropy production of molecular systems
Fluctuation relations
Fluctuation-dissipation relations
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