Welcome to Jin Yu Lab

We study physical mechanisms of bimolecular systems through quantitative modeling and large scale simulations. We try to understand how protein and nucleic acids function nicely to play their physiological roles. In particular, we focus on studying protein/DNA machinery, such as RNA polymerases, from an atomistic scale to their functional level, for example, in the gene transcription. By computationally investigating mechano-chemical couplings and informational control of such kinds of systems, we want to recognize how those molecular machines and related circuits operate with sufficiently high efficiency and fidelity despite of cellular noises and fluctuations. Furthermore, we want to understand how those delicate functionalities arise from evolution. The rationale can help molecular engineering and support further biomedical research.

Interested Areas

• Biophysics, modeling and computation

• Non-equilibrium statistical mechanics